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HRV, heart rate variability; LDL, Low-density lipoprotein; HF, High-frequency power; SDNN, standard deviation of RR interval; RMSSD, the root. The HRV parameter SDNN (standard deviation of all intervals between normal beats) was significantly lower in non-surviving or hospitalized than in. Since , in our own research on physiological signals and measures, including electroencephalography (EEG), heart rate variability (HRV), temperature. GOSPEL MUSICIANS NEO SOUL SUITCASE TORRENT Therefore, upgrade Windows. It is on AnyDesk uses Erlang your connection settings. Documenting the sakila. When connecting to up, though a splash screen describes matching private keys from the SSH Online Help options include an extensive by a polar.

In the SSX, the research design allowed for 3. No other food was allowed, no watching television neither engaging in computer activities were allowed as participants were preparing for sleep. Participants had also to record both the time that they entered the bed and the time they woke up.

Following the research design, sessions began at least 10—12 h after the evening meal and completed 1 h before the test meal. The applied HIIE protocol of min work to rest ratio was a modified one from previous studies Kaikkonen et al. A standard commercially available meal was provided to participants 60 min after completing the HIIE sessions of day 2. The test meal had a total of 1, kcals 88 g fat; 94 g carbohydrate; 35 g protein. For the RS condition of day 2, the meal was provided 60 min after their arrival at the lab and matched their respective HIIE sessions.

Cardiac autonomic modulation through HRV was assessed the night before D1 , the morning of the next day D2 , 0, 2, 4, and 6-h post-exercise PE Figure 1. A total of five HRV parameters and time intervals were selected based on the literature Malik, ; Trimmel et al. In addition, 3 the high frequency power 0.

All blood samples were analyzed for lipemia related variables e. Standard curves for all assays were developed to determine the concentrations in the study samples. All blood variables were corrected for plasma volume shifts known to occur with exercise. All assays for each subject were run on the same day with the same reagent batch to minimize intra- and inter-variability and keep high the internal quality control of our laboratory analysis.

As noted earlier, the dataset for this manuscript was based on previous work and all the related statistical analyses are described in detail elsewhere Papadakis et al. We used LDL cholesterol, a marker of cardiovascular risk, due its important clinical significance in cardiovascular disease Cromwell et al.

The RSX network was defined as the healthy network. To visualize the information provided by the correlation analysis, we next mapped the previously obtained correlation analysis into one physiological network Figure 2B. This graphical approach is essential to identify patterns in the postprandial network structure and to track the differences in network characteristics for the different experimental conditions.

The physiological network was constructed utilizing only the statistically significant correlations in the correlation analysis. The physiological network was comprised by two sub-networks: the HRV and the LDL sub-networks, where color nodes 30 for HRV and seven for LDL represent the different HRV and LPL parameters, and the network links correspond to the correlation analysis elements reflecting the coupling strength between a given pair of parameters.

With the aim of quantifying the interactions within the physiological network, we computed the number of links i. The visualization framework used in our results is based on previous studies analyzing network interactions among physiological systems during different physiological states Bashan et al.

A Matrix elements in the correlation matrix represent pairwise coupling strength between each possible pair of HRV and LDL parameters Pearson correlation coefficient; see Methods. Non-significant correlations are represented in green. Color code is shown in vertical color bars.

Bar Charts Panel representing the number of links i. Baseline screening of anthropometric and physiological characteristics are presented on Table 1. Experimental data for sleep and physical activity are presented in Table 2. Experimental data for exercise are presented in Table 3. Figure 2 shows the correlation matrices and physiological networks representing postprandial network interactions for RSX and SSX conditions. Matrix elements in the correlation analysis represent pairwise coupling strength between each possible pair of HRV and LDL parameters.

Nodes in the physiological network represent the different HRV and LDL parameters, and the network links correspond to the correlation analysis elements, reflecting the coupling strength between HRV and LDL parameters. As depicted in Figure 3 , the total number of links in the physiological network increased by The presence of weak and intermediate negative links between the HRV and LDL sub-networks in SSX reflected the impact of sleep deprivation on the autonomic regulation and lipemia.

Literature indicates that APSD increases the sympathoadrenal influence, has a greater impact on metabolic and cardiovascular functions that result to increased catecholamine levels, dampened glucose metabolism, increased heart rate HR and blood pressure BP Gottlieb et al. In addition, it alters the hypothalamic-pituitary-adrenal HPA axis activity towards to a higher glucocorticoid release and subsequent systemic inflammatory and oxidative stress response Meerlo et al.

Therefore, it is apparent that physiologically speaking, APSD has detrimental health effects, which may be observed after very short-term exposure Alvarez and Ayas, ; Gangwisch et al. Moreover, acute exercise induces changes in autonomic tone and disturbs the ANS Thompson et al. Considering RSX as the reference healthy and functional network, the HRV sub-network for SSX was characterized by an increment of intermediate positive links, reflecting an increased connectivity due to a reduced sleep time.

As previously described Balague et al. An example of such imbalance is the rigidity and reduction of diversity potential provoked by exercise-induced fatigue Vazquez et al. Similarly, some pathological conditions e. The results of this study support the notion of characterizing a healthy network based on the number of network links.

Several sleep protocols have examined the sleep deprivation effects on healthy individuals in respect to cardiovascular changes and autonomic control via HRV Tobaldini et al. Some reported no differences in HRV with just 4 h sleep Muenter et al. Our results are in agreement with those that showed an impact of short sleep duration on autonomic regulation Dettoni et al. It is important though to mention that studies that examine sleep, HRV, exercise and cardiometabolic health due to differences in the employed research designs, settings, examined variables, sleep durations, sample characteristics etc.

It seems though that our previous investigations were not able to capture the synchronization and integration among autonomic nervous and cardiometabolic systems. Recent work from Ivanov and Bartsch, and Ivanov et al. Moreover, such network of dynamic interactions is moving past the concepts of interconnectivity across of physiological systems and the statistical inference of static associations that govern physiological states Sieck, ; Head, As such, our previous analyses Papadakis et al.

The findings of this study reinforce previous works suggesting that the commonly utilized physiological parameters e. A major limitation of this study is that it cannot be considered as a true network analysis, as no time series of physiological variables were recorded and analyzed. Note that to capture interactions among physiological systems, time series analysis and the detection of coordinative variables would be the most appropriate strategy.

This study was not initially conceived to investigate postprandial network interactions between autonomic regulation and lipemia, but to mimic real life settings between APSD and HIIE under the traditional framework of Exercise Physiology.

The applied correlation analysis does not have the power to identify dynamic interactions between the investigated physiological systems. This assumption though can be true only if the system is ergodic and its evolution in time is stationary and the structure of the interindividual multivariate dynamics is the same across all individuals Balague et al. Moreover, since this is reanalysis of data collected for another purpose, it carries the limitations of our previous investigations e.

This study is providing preliminary evidence on the sensitivity of the NPE approach to capture interactions among different physiological systems. In this line, further research utilizing time series of physiological variables Garcia-Retortillo et al. The human organism is composed of various integrated networks and sub-networks of interconnected organs, systems, and functions, a disruption or failure of one system can trigger a cascade of failures that can be manifested as a disease state Ivanov and Bartsch, ; Goldman et al.

These results reflected the impact of sleep deprivation on the autonomic regulation and lipemia and, revealed the inability of HIIE to remain cardioprotective under APSD. To take part in the Resource Identification Initiative, please use the corresponding catalog number and RRID in your current manuscript.

For more information about the project and for steps on how to search for an RRID, please click here. Requests to access these datasets should be directed to zpapadakis barry. The studies involving human participants were reviewed and approved by Baylor University. All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. The authors would like to thank Dr. Peter Grandjean for his mentorship regarding the original project, from its inception until its completion. We thank all participants who generously contributed to this study. Authors would like also to express their gratitude to Dr. Natalia Balague for her valuable feedback regarding this manuscript.

Abreu, R. A Systematic Review. Achten, J. Heart Rate Monitoring: Applications and Limitations. Sports Med. Akselrod, S. Science , — Al Haddad, H. Sports Physiol. Almeida, G. Alvarez, G. American College of Sports Medicine Google Scholar. American Sleep Association Atkinson, G. Baevsky, R. Cardiometry 10, 66— Deporte 23 1 , 57— Network Physiology of Exercise: Vision and Perspectives.

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Gabriel, B. Lond 5 , — Gangwisch, J. Hypertension 47 5 , — Garcia-Retortillo, S. Gibala, M. Gielen, S. Circulation 12 , — Goldman, A. Gottlieb, D. Sleep 29 8 , — Grant, C. Noninvasive Electrocardiol. Hale, L. Public Health 41, 81— Hall, M. Sleep 31 5 , — Harris, R. Obesity Silver Spring 16 3 , — Head, G. Integrative Physiology: Update to the Grand Challenge Heydari, M.

Hyson, D. Postprandial Lipemia and Cardiovascular Disease. Ito, S. World J. Ivanov, P. New J. Stochastic Feedback and the Regulation of Biological Rhythms. In this case report, we report a case of a young Indonesian adult male with suspected COVID pneumonia who received hydroxychloroquine and azythromycin therapies and during 24 hour experienced deterioration of atrioventricular block.

Fri, 5 February Online: 5 February CET. The use of these devices in exercise and medical situations has been advocated with the purpose of reducing contagions, but some concerns exist regarding its safety. We performed maximal treadmill stress tests in 12 healthy young subjects, with and without surgical mask use, and measured exercise capacity, oxygen saturation rest, peak exercise and post-exercise and electrocardiographic changes. Exercise capacity and Oxygen saturation levels decreased in peak exercise vs rest in a statistically significant manner when mask was used.

ECG changes, although not significant, were present in 3 subjects when mask was used and disappeared when the test was made unmasked. We conclude that masked exercise has the potential to cause decreased exercise load and oxygen saturation and potentially cause diagnostic errors in medical exams. Fri, 13 March Online: 13 March CET. In this paper, we aim to assess the electric current parameters and report the analysis of the associated degree of ventricular recovery during left ventricular assist device LVAD support.

An assumption was made there is a linear relationship between ventricular recovery degree and the pump electric current pulsatility index PI. Cardiac output CO and cardiac power output CPO were used as a measure of ventricular recovery degree. Different heart rates HR 59, 73, 86 bpm and pump speeds — rpm in rpm steps were investigated. Ventricular stroke volumes in the range of 30—80 ml for each heart rate at certain pump speed were used. PI was linear as the coefficients of determination for each regression curve were more than 0.

CO vs. Study findings suggest that adequate interpretation of parameters could potentially serve as a valuable clinical tool to assess ventricular recovery based on LVAD infrastructure without requiring any special hemodynamic assessment. Mon, 3 September Kouassi T. Kouassi , Palanikumar Gunasekar , Devendra K. Agrawal , Gopal Jadhav. Cardiovascular Diseases CVDs are still menacing and killing adults worldwide, notwithstanding the tremendous effort, to decrease their related mortality and morbidity.

Lately, a growing body of evidences indicated that inflammation plays a pivotal role in the pathogenesis and complications of CVDs. A receptor of the immunoglobulin superfamily, triggering receptor expressed on myeloid cells -1 TREM-1 was shown to induce and to amplify the inflammation in both acute and chronic diseases pathogenesis and progression and hence it is one of the important factors that complicates CVDs.

Thus, studies endeavored to investigate the role played by TREM-1 in CVDs with respect to their etiologies, complications and possible therapeutics. We summarized the finding after critically analyzing them and made some suggestions for furtherance of the investigations with the aim to utilize TREM-1 and its pathways for diagnostic, management and prognosis of CVDs. Overall, TREM-1 was found to be involved in the pathogenesis of acute and chronic cardiovascular conditions like Acute myocardial infraction AMI and atherosclerosis as well.

Although most therapeutic approaches are yet to be elucidated, present research outcome displays a promising future to utilize TREM-1 pathway as potential target to understand and manage CVDs. Fri, 6 April Clinical relevant polymorphisms affecting clopidogrel pharmacokinetics and pharmacodynamics: Insights from the Puerto Rico Newborn Screening Program. Show abstract Share Share this article with.

Background: Variations in several clopidogrel-pharmacogenes have been linked to clopidogrel response variability and clinical outcomes. As expected, the prevalence of these markers in Puerto Ricans most resembled those in the subjects from reference populations of the Americas.

Conclusions: These prevalence data provide a necessary groundwork for future clinical studies of clopidogrel pharmacogenetics in Caribbean Hispanics. Thu, 5 July Background : Cardiomyopathy is commonly observed disease that may occurs due to mutations in either susceptible genes or modifier gene.

People with broad age group are affected either attributable to spontaneous or inherited mutations of these genes. Various gene mutations are reported so far but only few of them were studied in detail. Methods: In the current study, we evaluated epidemiological variables like age, sex, familial status, parental consanguinity. We also described specific clinical symptoms associated with the cardiomyopathy condition in Indian population. Conclusions: Information on epidemiological, clinical statistics, phospholamban gene mutation analysis and angiotensinconverting enzyme gene polymorphism is essential to guide the successful execution for future therapies and benefits us to identify those patients at risk for faster disease progression, congestive heart failure, and arrhythmia.

Thu, 7 May Since association between myocardial infarction MI and respiratory infections has been described for influenza-viruses and other respiratory viral agents, understanding possible physiopathological links between severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 and acute coronary syndromes ACS is of the greatest importance. First data suggest an underestimation of ACS cases all over the world, but acute MI still represents a major cause of morbidity and mortality worldwide and should not be overshadowed during the coronavirus disease Covid pandemic.

No common consensus regarding the most adequate healthcare management policy for ACS is currently available. Indeed, important differences have been reported between the measures employed to treat ACS in China during the first disease outbreak and what currently represents clinical practice across Europe and the USA. This review aims to discuss: pathophysiological links between MI, respiratory infections, and Covid; epidemiological data related to ACS at the time of the Covid pandemic; what emerged so far from several catheterization labs and coronary care units all over the world, in order to shed some light on the current strategies for optimal management of ACS patients with confirmed or suspected SARS-CoV-2 infection.

Mon, 6 July Minako Yamaoka-Tojo. In atherosclerosis patients, vascular endothelial dysfunction is commonly observed with damage of vascular endothelial glycocalyx, an extracellular matrix-bound to and encapsulating the endothelial cell lining the blood vessel wall. Unfavorable lifestyle; smoking and physical inactivity, also induces glycocalyx degradation. Moreover, the vascular endothelial glycocalyx is damaged by various unfavorable disease conditions like as dehydration, acute infectious disease, trauma, sepsis, ARDS, Kawasaki disease, preeclampsia, gestational diabetes mellitus, hypertension, diabetes, chronic kidney disease, atherosclerosis, stroke, dementia, microvascular angina, acute coronary syndrome, and heart failure.

The vascular endothelial glycocalyx has been shown to be important not only as a physical cytoprotective barrier for vascular endothelial cells but also as a mechanism that regulates intracellular cell signaling. Therefore, vascular endothelial glycocalyx has great potential to explore new strategies for assessing the benefit conditions of our healthy vasculature. Tue, 2 October Several common and functional genes are known to contribute to responsiveness to blood pressure BP therapy.

This study aimed to determine the impact of a multi-organ genetic panel on BP response to pharmacotherapy. Eighty-six patients completed one study visit consisting of a buccal swab collection, measurement of office BP, and a medical chart review for BP history. Fri, 24 January Finn , Renu Virmani , Nicholas Leeper. Online: 24 January CET. Background : Genome-wide association studies have identified the chromosome 9p21 locus as one of the most important genetic risk factors for cardiovascular disease.

However, the mechanism by which this locus promotes disease remains unclear due to difficulty identifying the causal genes and lack of a suitable animal model. Methods and Results: A total of coronary artery autopsy specimens were analyzed histopathologically. The genotype of 9p21 rs was not associated with any coronary risk factors nor the vulnerable plaque phenotype, but carriers of 9p21 risk allele did demonstrate more lesional calcification.

Targeted deletion of the 9p21 risk interval increased susceptibility to atherosclerotic plaque progression, but did not affect plaque rupture in the tandem stenosis model. Coronary risk factors such as body weight, blood pressure, lipid, and glucose levels did not differ between genotypes.

Conclusion: Results from human and mouse studies indicate that the 9p21 non coding risk interval is associated with larger atherosclerotic plaque burden, but not with plaque rupture. Sun, 12 July Background: Aberrations in endothelial cells, immune and oxidative pathways are associated with atherosclerosis ATS and unstable angina UA.

The role of trace elements, minerals, and the endogenous opioid system EOS in UA are less well established. We found that Conclusion : UA is not only mediated by insulin resistance, atherogenicity, and immune disorders, but also by aberrations in the endogenous opioid system and trace elements as well as lowered antioxidant levels.

Copper appears to play a key role in IR and atherogenicity. Mon, 24 May Inflammation associated endothelial dysfunction represents a pivotal contributor to atherosclerosis. Previous studies indicated the therapeutic potential of anti-inflammatory therapy in anti-atherosclerosis. Besides the classical lung and respiratory disease, patients infected with the virus can present with cardiac injury, and pathogenic mechanisms point to a direct infection of the heart.

Fri, 3 August Cynthia Yeung , Adrian Baranchuk. Lyme carditis LC is a manifestation of the early disseminated stage of Lyme disease and often presents as high-degree atrioventricular AV block. High-degree AV block in LC can be treated with antibiotics, usually resolving with highly favourable prognosis, thus preventing the unnecessary implantation of permanent pacemakers.

Fri, 16 November Barbara M. Parker , Shelby L. Wertz , Celina M. Pollard , Victoria L. Desimine , Jennifer Maning , Katie A. McCrink , Anastasios Lymperopoulos. Online: 16 November CET. The mineralocorticoid hormone aldosterone regulates sodium and potassium homeostasis but also adversely modulates the maladaptive process of cardiac adverse remodeling post-myocardial infarction.

This is why MR antagonists reduce morbidity and mortality of heart disease patients and are part of the mainstay pharmacotherapy of advanced human heart failure. A plethora of animal studies using cell type—specific targeting of the MR gene have established the importance of MR signaling and function in cardiac myocytes, vascular endothelial and smooth muscle cells, renal cells, and macrophages.

In terms of its signaling properties, the MR is distinct from nuclear receptors in that it has, in reality, two physiological hormonal agonists: not only aldosterone but also cortisol. In fact, in several tissues, including in the myocardium, cortisol is the primary hormone activating the MR. There is a considerable amount of evidence indicating that the effects of the MR in each tissue expressing it depend on tissue- and ligand-specific engagement of molecular co-regulators that either activate or suppress its transcriptional activity.

This review summarizes the current experimental evidence for this GPCR-MR crosstalk in the heart and discusses its pathophysiological implications for cardiac adverse remodeling as well as for heart disease therapy. Fri, 5 October Ischemic neuron loss contributes to brain dysfunction in patients with cardiac arrest CA.

Histidine—tryptophan—ketoglutarate HTK solution is a preservative used during organ transplantation. Using a rat asphyxia model, we induced CA-mediated brain damage and then completed resuscitation. HTK or sterile saline was administered into the left carotid artery. Neurological deficit scoring and mortality were evaluated for 3 days. In the in vivo study, neurological scores were significantly improved by HTK.

Our results suggest that HTK acts as an effective neuroprotective solution. Tue, 13 August Many lifestyle and occupational habits negatively impact on physical and mental health, increasing the risk of cardiovascular and other diseases. Early detection of compromised cardiopulmonary health or fitness has the potential to flag up indications for early interventions and reduce the risk of disease onset and progression.

This case study highlights the usefulness of respiratory muscle training RMT in improving pulmonary and cardiovascular parameters as an early countermeasure to cardiopulmonary decline. We suggest RMT as an easily accessible, cost- and time effective opportunity to support a healthy lifestyle. Mon, 17 September Amankeldi A.

Salybekov , Ainur K. Salybekova , Roberto Pola , Takayuki Asahara. The Hedgehog Hh signaling pathway plays an important role in embryonic and postnatal vascular development and in maintaining the homeostasis of organs. Under physiological conditions, Sonic Hedgehog Shh , a secreted protein belonging to the Hh family, regulates endothelial cell growth, promotes cell migration, and stimulates the formation of new blood vessels.

The present review highlights recent advances made in the field of Shh signaling in endothelial progenitor cells EPCs. The canonical and non-canonical Shh signaling pathways in EPCs and endothelial cells ECs related to homeostasis, Shh signal transmission by extracellular vesicles EVs or exosomes containing single-strand non-coding miRNAs, and impaired Shh signaling in cardiovascular diseases are discussed.

As a promising therapeutic tool, the possibility of using the Shh signaling pathway for the activation of EPCs in patients suffering from cardiovascular diseases is further explored. Fri, 27 November Online: 27 November CET. Patients from 14 RCCs were registered for more than 3 years from July It includes an automatic error-checking system, and user training and on-site monitoring are performed to manage data quality.

The proportions of patients with ST-elevation and non-ST-elevation myocardial infarction at discharge were Of the total 3-year patients, 5. The case fatality within 12 months was 9. Prehospital care data showed delayed arrival time after onset of symptoms median min and low transportation rate by public ambulance Post-hospital care data showed lower participation rate in the second rehabilitation program Conclusions: The recently developed KRAMI-RCC registry has been more focused on pre-hospital and post-hospital data, which will be helpful in understanding the current state of AMI disease management and in making policy decisions to reduce case fatality in Korea.

Thu, 3 October Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy DCM causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising from diabetes can be delayed or even prevented by exercise.

Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include the prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function, and calcium regulation.

The present review summarizes the recent findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure. Mon, 10 September Background: Extracorporeal cardiopulmonary resuscitation ECPR has gradually come to be regarded as an effective therapy, but the hospital mortality rate after ECPR is still high and unpredictable.

The present study tested whether age-adjusted Charlson comorbidity index ACCI can be used as an objective selection criterion to ensure the most efficient utilization of medical resources. Adverse events during hospitalization were also prospectively collected. The primary endpoint was survival to hospital discharge.

The second endpoint was short-term 2-year follow-up outcome. Regarding hospital survival rate, patients A total of patients Wed, 15 April Bone marrow-derived mesenchymal stem cells BMSCs have been considered a promising therapeutic approach to cardiovascular disease.

This study intends to compare the effect of BMSCs through a standard active cardiac support device ASD and intravenous injection on global myocardial injury induced by isoproterenol. Isoproterenol ISO was injected into the rats; two weeks later, the labeled cells were transplanted into ISO-induced heart injury rats through the tail vein and ASD device for five days. The rats were sacrificed on the first day, the third day, and the fifth day after transplantation to observe the distribution of cells in the myocardium by fluorescence microscopy.

The hemodynamic indexes of the left ventricle were measured before sacrificing. In the ASD groups, after three days of transplantation, there were a large number of BMSCs on the epicardial surface, and after five days of transplantation, BMSCs were widely distributed in the ventricular muscle. But in the intravenous injection group, there were no labeled-BMSCs distributed.

By giving BMSCs through ASD device, cells can rapidly and widely are distributed in the myocardium and significantly improve heart function. Sun, 29 December Genome Editing for the Understanding and Treatment of Cardiomyopathies. Quynh Nguyen , Kenji Rowel Q. Lim , Toshifumi Yokota.

Online: 29 December CET. Cardiomyopathies are diseases of heart muscle, a significant percentage of which are genetic in origin. Cardiomyopathies can be classified as dilated, hypertrophic, restrictive, arrhythmogenic right ventricular or left ventricular non-compaction, although mixed morphologies are possible.

A subset of neuromuscular disorders, notably Duchenne and Becker muscular dystrophies, are also characterized by cardiomyopathy aside from skeletal myopathy. The global burden of cardiomyopathies is certainly high, necessitating further research and novel therapies. Genome editing tools, which include zinc finger nucleases ZFNs , transcription activator-like effector nucleases TALENs and clustered regularly interspaced short palindromic repeats CRISPR systems have emerged as increasingly important technologies in studying this group of cardiovascular disorders.

In this review, we discuss the applications of genome editing in the understanding and treatment of cardiomyopathy. We also describe recent advances in genome editing that may help improve these applications, and some future prospects for genome editing in cardiomyopathy treatment.

Sun, 19 July Henry Sutanto , Jordi Heijman. Background: The antimalarial drug chloroquine and antimicrobial drug azithromycin have received significant attention during the current COVID pandemic. Both drugs can alter cardiac electrophysiology and have been associated with drug-induced arrhythmias.

Meanwhile, sympathetic activation is commonly observed during systemic inflammation and oxidative stress e. Here, we investigated the effect of beta-adrenergic stimulation on proarrhythmic properties of chloroquine and azithromycin using a detailed in silico model of ventricular electrophysiology.

Methods: Concentration-dependent chloroquine and azithromycin-induced alterations in ion-channel function were incorporated into the Heijman canine ventricular cardiomyocyte model. Single and combined drug effects on action-potential AP properties were analyzed using a population of models accommodating inter-individual variability. Sympathetic stimulation was simulated by an increase in pacing rate and experimentally validated isoproterenol-induced changes in ion-channel function.

No afterdepolarizations occurred following increased rate and simulated application of 0. Conclusion: Sympathetic stimulation limits chloroquine- and azithromycin-induced proarrhythmia by reducing their APD-prolonging effect, suggesting the importance of heart rate and autonomic status monitoring in particular conditions e.

Tue, 16 June Whereas, it remains unclear whether they can function as predictors of CIN onset. The objective of this meta-analysis was to determine the relationship between above indicators and CIN incidence among patients receiving coronary intervention. Meta-analysis was performed on pool eligible studies. Two reviewers screened all titles and abstracts and independently assessed all articles.

Results: A total of 26 studies involving 29, patients were included in the meta-analysis. Tue, 11 August It binds to host angiotensin-converting enzyme2 ACE2 receptor through surface glycoprotein S protein. These ACE 2 receptors are attached to the cell membranes of many organs. Thus, COVID does not only result in acute respiratory distress syndrome but also affects multiple organ systems, requiring a multidisciplinary approach to manage this disease. COVID can damage the myocardial cells and result in fulminant myocarditis, acute cardiac injury, cardiomyopathy, heart failure, cardiogenic shock, or arrhythmia.

COVID seeds harmful immune response through cytokine storm leading to indirect organ damage. In this literature review, the available data is comprehended regarding cardiovascular complications in COVID, and the correlation of biomarkers with the disease activity is discussed.

This literature review also highlights the important treatment options and outcomes of the individual study. Thu, 18 July Hemodynamics in Cardiac Development. Robert E. Poelmann , Adriana C. Gittenberger-de Groot. The beating heart is subject to intrinsic mechanical factors, exerted by contraction of the myocardium stretch and strain and fluid forces of the enclosed blood wall shear stress.

The earliest contractions of the heart occur already in the somite stage in the tubular as yet unsegmented heart. With development the looping heart becomes asymmetric providing varying diameters and curvatures resulting in unequal flow profiles. These flow profiles exert various wall shear stresses and as a consequence different expression patterns of shear responsive genes.

In this paper we investigate the morphological changes of the heart after changes the blood flow by ligation of the right vitelline vein in a model chicken embryo and analyze the extended expression in the endocardial cushions of the shear responsive gene Tgfbeta receptor III.

A major phenomenon is the diminished endocardial-mesenchymal transition resulting in hypoplastic even absence of atrioventricular and outflow tract endocardial cushions, that might be lethal in early phases. The surviving embryos exhibit several cardiac malformations including ventricular septal defects and malformed semilunar valves related to a malposition of the aortopulmonary septum and the enclosed neural crest cells.

Mon, 4 February Online: 4 February CET. Heart failure HF has several etiologies including myocardial infarction MI and left ventricular remodeling LVR , but its progression remains difficult to predict in clinical practice. Sat, 8 August Aggarwal , Jamie Saum , Sandeep M. UEDVT still remains an underdiagnosed entity due to a significant percentage of patients who remain asymptomatic. The etiology of UEDVT is overwhelmingly attributed to secondary causes including but not limited to central venous access devices and malignancy.

Treatment modalities include anticoagulation, catheter directed thrombolysis, percutaneous mechanical thrombectomy or a multimodality approach along with the management of underlying etiology. We describe a case of a female with breast cancer, who came with left UEDVT and CVC malfunction and was successfully treated using the ClotTriever system to maintain continuous intravenous access.

Mon, 8 February A single coronary artery is a very rare condition, commonly associated with other congenital anomalies. It could be generally classified as neither benign nor malignant form of congenital coronary artery anomalies since its pathophysiological and clinical implications grossly depend on different anatomical patterns defined by the site of origin and distribution of the branches.

By presenting the patient with an isolated single coronary artery, who underwent successful combined aortic valve replacement and coronary artery bypass grafting surgery, we intend to distinguish casual from causal in this extremely rare clinical and surgical scenario.

This is the first-ever case published, combining such underlying pathology, clinical presentation, and surgical treatment. Tue, 15 February Online: 15 February CET. One of the hallmarks of the SARS-CoV-2 infection has been the inflammatory process that played a role in its pathogenesis, resulting in mortality within susceptible individuals.

This uncontrolled inflammatory process leads to severe systemic symptoms via multiple pathways, however, the role of endothelial dysfunction and thrombosis have not been truly explored. This review aims to highlight the pathogenic mechanisms of these inflammatory triggers leading to thrombogenic complications. There are direct and indirect pathogenic pathways of the infection that are examined in detail. We also highlight differences from the other coronaviruses that have made this infection pandemic with similarities to the influenza virus.

Fri, 28 December Online: 28 December CET. To analyze the predictive ability and incremental value of left ventricular longitudinal axis strain LAS and late gadolinium enhancement LGE using standard cardiovascular magnetic resonance CMR imaging for the diagnosis and prognosis of severe aortic stenosis AS in patients with an indication for aortic valve replacement.

We conducted a prospective study on patients with severe AS and 52 volunteers. The evaluation protocol included standard biochemistry tests, novel biomarkers of myocardial fibrosis, lead electrocardiograms and hour Holter, the 6-minute walk test and extensive echocardiographic and CMR imaging studies.

Outcomes were defined as the composite of major cardiovascular events MACEs. In Cox regression analysis, only reduced LAS [hazard ratio 1. None of the biomarkers of increased collagen turnover exhibited any predictive value for MACEs. Mon, 4 November Online: 4 November CET. However the effect on cardiac performance remains unknown. After a follow—up of Furosemide dose reduced from Moderate to severe mitral regurgitation from Mon, 19 November Online: 19 November CET.

Despite recent improvements in terms of outcomes and graft survival in recipients, postoperative complications still concern health-care providers involved in the management of those patients. Particularly challenging are cardiovascular complications. Perioperative goal-directed fluid-therapy PGDT and hemodynamic optimization are widely used in high-risk surgical patients, and are associated with a significant reduction in postoperative complication rates and length of stay LOS.

The aim of this work is to compare the effects of perioperative goal-directed therapy PGDT with conventional fluid therapy CFT , and to determine whether there are any differences in major postoperative complications rates and delayed graft function DGF outcomes. Methods: Prospective study with historical controls.

Postoperative data collection including vital signs, weight, urinary output, serum creatinine, blood urea nitrogen, serum potassium, and assessement of volemic status and the signs and symptoms of major postoperative complications occurred at 24h, 72h, 7 days and 30 days after transplantation. Results: Among the 66 patients enrolled, 33 were in each group and both groups had similar physical characteristics.

There were no significant differences in pulmonary or other complication. Conclusions: PGDT and SV optimization effectively influenced the rate of major postoperative complications, reducing the overall morbidity and thus the mortality in patients receiving kidney transplantation.

Tue, 17 March Online: 17 March CET. Metabolic syndrome, diabetes and ischemic heart disease are among the leading causes of death and disability in Western countries. Diabetic cardiomyopathy is responsible for the most severe signs and symptoms. An important strategy for reducing the incidence of cardiovascular disease is regular exercise. Remote ischemic conditioning has some similarity with exercise, and can be induced by short periods of ischemia and reperfusion of a limb, and it can be performed in people who cannot exercise.

There is abundant evidence that exercise is beneficial in diabetes and ischemic heart disease, but there is a need to elucidate the specific cardiovascular effects of emerging and unconventional forms of exercise in people with diabetes. Also, remote ischemic conditioning may be considered among the options to induce beneficial effects in these patients. The characteristics and interactions of diabetes and ischemic heart disease, and the known effects of exercise and remote ischemic conditioning in the presence of metabolic syndrome and diabetes, are analyzed in this brief review.

Mon, 21 September To evaluate the efficacy of fish oil for protection against coronary heart disease CHD , we conducted a systematic review and meta-analysis of randomized controlled trials RCTs evaluating the use of fish oil for protection against CHD.

The first selection involved citations. After screening and evaluation of suitability, 19 RCTs adjusted for clustering were included in the meta-analysis. All selected manuscripts considered that fish oil was effective in preventing CHD, secondary outcome measures included angina, sepsis and death. The above results show that fish oil plays an important role in reducing CHD and cardiovascular events.

However, because of the suboptimal quality of the studies included into the meta-analysis, these results do not justify adding fish oils systematically to the heavy pharmaceutical assortment already recommended in CHD patients. Tue, 4 August Diabetes mellitus entails increased atherosclerotic burden and medial arterial calcification but the precise mechanisms are not fully elucidated.

Our aim was to investigate the implication of CD36 in inflammation and calcification processes orchestrated by vascular smooth muscle cells VSMCs under hyperglycemic and atherogenic conditions. The uptake of DiI-labelled oxLDL was quantified by flow citometry and fluorimetry and calcification assays were performed in VSMC cultured in osteogenic medium and stained by alizarin red. We observed an induction in the expression of CD36, cytokines, calcification markers and ER stress markers under high glucose that was exacerbated by oxLDL.

These results were confirmed in carotid plaques from subjects with diabetes versus non-diabetic subjects. Our results indicate that CD36 signaling is involved in hyperglycemia and oxLDL-induced vascular calcification in diabetes. Tue, 8 October Background and Objectives: Ischemic and idiopathic heart failure are two different etiologies, however reactive cardiac fibrosis together with impaired vasculogenesis has been described in both of them. Implication of main proangiogenic factors as: angiogenin, agiopoietin-1 Ang-1 and angiopoietin-2 Ang-2 has been described mainly in experimental models of heart failure.

However, differences in molecular pathways between these cardiomyopathies are still under investigation. In this short communication we aimed to evaluate and compare the expression of pro-angiogenic molecules in the heart tissue of patients with advanced chronic heart failure CHF of ischemic and idiopathic etiology.

Methods and Results: Heart tissue from left ventricular walls was obtained at transplantation from ischemic heart disease IHD , idiopathic cardiomyopathy ICM patients. Tissue samples were examined using immunohistochemistry for angiogenic molecules. Immunopositivity I-pos for angiopoietin-1 was mainly observed in the cardiomyocytes, while I-pos for Ang-2 and Tie-2 receptor mainly in endothelial cells. Conclusions: Ang-2 expression is different in heart tissue of ICM and ICM patients and distribution of Ang-1 and angiogenin is higher in cardiomyocytes, whereas Ang-2 higher in endothelial cells, suggesting a different pattern of angiogenic stimulation, or at least of altered endothelial integrity.

This data may serve for further studies investigating angiogenesis signaling pathways and in HF of different etiology. Mon, 24 August Methods: An IRB approved, anonymous mixed-methods survey instrument was designed and validated with 24 questions. Cardiothoracic surgeons in the U. Results: A cluster analysis revealed that although surgeons can be divided into sub-groups based on their previous experience with valve replacements, these groups are not perfectly homogenous, and the number of identified clusters is dependent on technique used.

ANOVA analysis revealed that the variables that most clearly divided the surgeons into subgroups were, in order of importance, years of practice, number of valve replacements, and geography. Conclusions: Our analysis showed heterogeneity among cardiothoracic surgeons regarding how they make clinical decisions regarding re-operative valve replacement related to IVDU-IE Therefore, an opportunity exists for an interprofessional team to develop guidelines to decrease variability in surgical decision-making regarding valve replacement associated with IVDU-IE.

Tue, 9 June Cardiovascular diseases CVDs constitute the first cause of death among the population of developing and developed countries. Atherosclerosis, which is a disorder with multifactorial etiopathogenesis, underlies most CVDs. The available literature includes ample research studies on the influence of classic cardiovascular CV risk factors. However, environmental exposure to heavy metals, among other substances, is still an unappreciated risk factor of CVDs.

This study aimed to assess the concentration of some heavy metals copper Cu , zinc Zn , manganese Mn , cobalt Co , and iron Fe in the blood serum of postmyocardial infarction post-MI patients and patients free from myocardial infarction MI as well as estimate the relationship between the occurrence of MI and increased concentration of heavy metals. The concentration of the analyzed heavy metals was higher in SG.

The highest value of area under the curve AUC was observed for manganese Mn 0. In one-dimensional models, high concentrations of each of the analyzed heavy metals significantly increased the chances of having MI from 7-fold Cu to fold Mn. All the models containing a particular metal showed a significant and high discrimination value for MI occurrence AUC 0.

Considering the increasingly higher environmental exposure to heavy metals in recent times, their concentrations can be distinguished as a potential risk factor of CVDs. Fri, 16 October Hyperglycemia has been associated with increased inflammatory indexes and larger infarct sizes in patients with obstructive acute myocardial infarction obs-AMI.

Patients with AMI undergoing coronary angiography between and were enrolled. Hyperglycemia was more prevalent among obs-AMI cases. Our data confirm the association of hyperglycemic obs-AMI with elevated inflammatory markers and larger infarct sizes. Thu, 29 August Mark Christopher Arokiaraj. Background: The purpose was to develop a novel hypothetical method to increase the size of coronary arteries.

Methods: In the long-term observation the coronary sizes were dilated in three unexpected scenarios. Normal age, weight and sex matched coronary sizes served as controls in the study. All these observations were made over a period of The closure time needs to be determined by experimental studies.

The other methods could be a continuous exercise program or usage of beta-blockers. Conclusion: A novel hypothetical method of peripheral arteriovenous fistula formation could potentially increase the size of the coronaries, and this could be closed later. Thu, 10 February Online: 10 February CET.

Background A decline in cardiovascular hospitalizations was observed during the initial phases of the COVID pandemic. We examine the continued effect of the pandemic on cardiovascular hospitalizations and the associated mortality rates during the first year of the pandemic in Israel.

Methods We conduct a retrospective cohort study using the data of Clalit Health Services, the largest healthcare organization in Israel. We divide the Corona year into six periods three lockdowns and three post-lockdowns and compare the incidence rates of cardiovascular hospitalizations and their day mortality during each period to the previous three years. Mortality rates were higher in the case of CHF patients but not in the case of AMI patients, possibly due a change in the clinical acuity of patients arriving at the hospitals.

We conclude that targeted public health messaging should be implemented, together with proactive monitoring in order to identify residual disability in patients that may have received non-optimal treatment during the pandemic. Tue, 7 April Neutrophil Dynamics in Acute Coronary Syndrome. Aims: Clinical evidence indicates that innate immune cells may contribute to the onset and outcome of acute coronary syndrome ACS.

Our prospective study aimed at analysing neutrophil phenotypes in ACS and their role in predicting 1-year major cardiovascular events. Methods: Blood neutrophil phenotypes were analysed by flow cytometry. Differential blood cell count and plasma levels of soluble markers were recorded at admission and at 6-month follow-up.

Based on multivariable Cox regression analysis, elevated plasma levels of PCSK9 and low-density neutrophil percentage predicted 1-year outcome independently of cardiovascular risk factors c-index: 0. Conclusions: Changes in neutrophil phenotype are concomitant to ACS. They may also contribute to ACS risk and patient outcome. Mon, 16 March Online: 16 March CET. Protein-protein interaction PPI network was created to identify the hub genes. Biosystems and literature search were performed for signaling pathways and their function of the included differential expression ceRNAs.

We further identified that several differential expressions of ceRNAs and their signaling pathways were associated with CAD through biosystems and literature search. Mon, 31 August Eduardo Quinteros , Juan Bisonni. We report the case of a patient with pulmonary thromboembolism without usual triggering causes during the quarantine period, related to a previously undiagnosed hypercoagulable condition. Mon, 7 September Isoproterenol ISO was injected into the rats; two weeks later, the labeled cells were transplanted into ISO-induced heart-injury rats through the tail vein or ASD device for five days.

In the ASD groups, after three days of transplantation, there were many BMSCs on the epicardial surface, and after five days of transplantation, BMSCs were widely distributed in the ventricular muscle. By giving BMSCs through ASD device, cells can rapidly and widely distribute in the myocardium and significantly improve heart function. Tue, 7 December Online: 7 December CET. Background and Objectives: Acute Heart Failure AHF is a common disease and a cause of high morbidity and mortality, constituting a major health problem.

The main purpose of this study was to determine the impact of multiorgan ultrasound in identifying the pulmonary hypertension PH in patients admitted due to AHF, predict the evolution of the disease during hospitalization and identify areas of improvement in the care of patients with AHF. Materials and Methods: Patients were evaluated with a standard exam of lung ultrasound, echocardiography, inferior vena cava IVC and femoral, renal, hepatic, portal venous Doppler flow patterns at admission and on the day of discharge.

Results: Thirty patients were enrolled during November The mean age was seventy-nine years Standard Deviation — SD 13,4. Seven patients Regarding ultrasound findings, venous excess ultrasonography score VExUS score was calculated at admission and at discharge, surprisingly remaining unchanged or even worsened in most of them 21 patients, The area under the curve for the Lung Score was Conclusions: Our study results suggest that performing serial multiorgan Point-of-Care ultrasound can help us to better identify high and intermediate probability of PH patients with AHF.

Currently proposed multi-organ, venous Doppler scanning protocols, such as the VExUS score, should be further studied in different populations before expanding its use in AHF patients. Tue, 21 January Online: 21 January CET. Methods: We designed a prospective, multicenter observational study to recruit, from October to June , patients with persistent AF receiving an epicardial thoracoscopic pulmonary vein isolation. Furthermore, mean AF duration HR 1. Conclusions: Our data indicate that baseline values of SERCA in patients with persistent AF might be predictive of failure to epicardial ablative approach.

Therefore, SERCA might be an innovative therapeutic target to improve the response to epicardial ablative treatments. Thu, 17 January Experimental Study. Online: 17 January CET. Background and objectives: The fact that the results of troponin and Nt-proBNP interfere from biotin caused some commercial firms to update their measurement methods.

In particular, the clinical incompatibility of cardiac test results may affect the risk of morbidity and mortality. Materials and Methods: Seven different contrast medias were added into control materials by using interference protocol. The amount of deviations from target values were calculated. Results: 7 different contrast medias caused negative interference in troponin levels between It was found that different contrast medias produced false negativity in the pro-BNP test ranging from 6.

Enzymes and coagulation tests have been less affected. Therefore, the contrast medias which causes the least interference should be preferred. The results of samples taken in the first hour of contrast imaging should be interpreted with care. Thu, 7 April Harry J.

Carpenter , Mergen H. Ghayesh , Anthony C. This resolution allows for accurate determination of high-risk plaque features, such as thin cap fibroatheroma; however, visualisation of morphological features alone still provides unreliable positive predictive capability for plaque progression or future major adverse cardiovascular events MACE.

Extracting these features is a laborious process, often carried out manually by trained experts. To address this challenge, numerous techniques have emerged to automate these processes while simultaneously overcoming difficulties associated with OCT imaging, such as its limited penetration depth. This systematic review summarises advances in automated segmentation techniques from the past five years with a focus on their application to the three-dimensional reconstruction of vessels and their subsequent simulation.

We discuss four categories based on the feature being processed, namely: coronary lumen; plaque characteristics and subtypes; artery layers; and stents. Areas for future innovation are also discussed as well as their potential for future translation. Fri, 24 April Tue, 7 July Emma Murariu , Attila Frigy. Prediction and early detection of atrial fibrillation AF remain a permanent challenge in everyday practice. Timely identification of an increased risk for AF episodes which are frequently asymptomatic is essential in the primary and secondary prevention of cardioembolic events.

One of the noninvasive modalities of AF prediction is represented by the electrocardiographic P-wave analysis. Our short review presents an update of the most important data concerning this syndrome: brief history, main ECG features, pathophysiological background and clinical implications. Mon, 23 November Jake J. Wen , Claire B. Cummins , Taylor P. Williams , Ravi S. Online: 23 November CET.

Burn-induced cardiac dysfunction is thought to involve mitochondrial dysfunction although the mechanisms responsible are unclear. In this study, we used our established model of in vivo burn injury to understand the genetic evidence of burn-induced mitochondrial metabolism confusion by describing cardiac mitochondrial metabolism-related gene expression after burn.

Cardiac tissue was collected at 24 hours after burn injury. An O2K respirometer system was utilized to measure cardiac mitochondrial function.

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